Ivan Krstić, the second keynote speaker, at the FIRST 2008 conference talks about how each component within a system from the CPU, motherboard, graphics card, coolant system up to the hard disk and network card could be hacked or have malware inserted.
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Ivan is currently on leave from Harvard University and was previously director of security architecture at One Laptop per Child (OLPC), an educational technology non-profit.
You can read more from him on http://radian.org/notebook/
And find out more about FIRST on www.first.org
With special thanks to ghostbrain for providing the podcast background music.