The Chicago Sun-Times is set to test a paywall system that would give readers access to online content in return for Bitcoin donations or tweets.
On 1 February, the newspaper will trial the system for 24 hours in partnership with BitWall, a San Francisco-based startup that provides monetisation strategies to news sites.
"We continue to experiment and test new technologies that we believe engage our readers and look forward to being the first major USA newspaper to test a Bitcoin-based paywall," Jim Kirk, Editor and Chief of the Chicago Sun-Times, said in a statement.
The ninth largest newspaper in the US will also grant access to readers who tweet about the Taproot Foundation, a non-profit set up to offer support to other non-profits.
"Technology is driving social innovation and impact in new and exciting ways," said Taproot Foundation executive Elizabeth Schwan-Rosenwald. "Kicking off 2014, Taproot is thrilled to be the recipient of an innovative collaboration between BitWall and the Chicago Sun-Times."
"As Taproot builds a national pro bono movement we are so pleased to be a part of the collaboration between Bitwall and the Chicago Sun-Times."
Earlier this week, the first ever insured storage service for Bitcoin owners was launched in London, in what is yet another step towards the cryptocurrency becoming a legitimate currency.
The volatile nature of Bitcoin has attracted naysayers who claim that cryptocurrencies are intrinsically over-valued. However, its growing popularity has led to many companies to accept Bitcoin as a legitimate form of payment in recent months.